The Barca captain's contract expires this summer and his futures is up in the air having been linked with a move away ever since his attempts to leave the club last summer were unsuccessful.
New president Joan Laporta has vowed to keep the Argentinean at the club, but thus far no new deal has been forthcoming.
"I hope it's not (Messi's last Clasico), I want him to stay at Barcelona, it's good for the Spanish league," Zidane told a news conference.
"We know what a player he is, but they're a very good team and we'll have to try and stop them playing to their strengths and be as good as we can be on the ball and play as best as we can."
Real's club captain Sergio Ramos is another player whose contract expires at the end of the season, and Zidane reiterated his hope that the 35-year-old has not faced Barca for the final time, either.
"Hopefully he's not played his last Clasico. He won't be fit tomorrow, which is a shame, but I hope he stays here," the French coach said.
Zidane will also be without Raphael Varane, who continues to isolate following a positive COVID-19 test, however Dani Carvajal and Eden Hazard have returned to training.
Champions Real currently sit third in La Liga, three points off leaders Atletico and two behind Barca in second place.
Defeat would make it very difficult for them defend their title. However, Zidane insisted they were thinking about nothing but victory.
"I'm not thinking about losing or losing ground," he said.
"We'll see what the situation is at the end of the game; we're going to give our all, we're positive and want to play our best game."
No comments
To be able to write a comment, you have to be registered and logged in
Currently there are no comments.